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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTT
All Species:
29.39
Human Site:
S417
Identified Species:
71.85
UniProt:
P42858
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P42858
NP_002102.4
3144
347860
S417
E
S
G
G
R
S
R
S
G
S
I
V
E
L
I
Chimpanzee
Pan troglodytes
XP_517080
3149
348077
S419
E
S
G
G
R
S
R
S
G
S
I
V
E
L
I
Rhesus Macaque
Macaca mulatta
XP_001086119
3133
346092
S406
E
S
G
G
R
S
R
S
G
S
I
V
E
L
I
Dog
Lupus familis
XP_536221
3130
346235
S401
P
G
C
R
S
R
S
S
S
I
V
E
L
L
A
Cat
Felis silvestris
Mouse
Mus musculus
P42859
3119
344672
S396
E
A
R
G
R
G
R
S
G
S
I
V
E
L
L
Rat
Rattus norvegicus
P51111
3110
343743
S387
E
A
G
G
R
G
R
S
G
S
I
V
E
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420822
3095
343993
S363
E
S
A
I
R
S
R
S
G
S
I
V
E
L
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_571093
3121
346651
S362
E
M
E
S
R
A
R
S
G
S
I
L
E
L
I
Tiger Blowfish
Takifugu rubipres
P51112
3148
348918
S362
D
I
E
S
R
A
R
S
G
S
I
L
E
L
I
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001122101
2627
296240
P104
A
Y
V
F
N
L
I
P
C
I
V
T
I
A
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.2
95.6
91.3
N.A.
90.5
89.9
N.A.
N.A.
82.9
N.A.
72.1
70.8
N.A.
29.7
N.A.
N.A.
Protein Similarity:
100
98.6
96.7
94.6
N.A.
94.3
93.8
N.A.
N.A.
90.5
N.A.
84.3
82.6
N.A.
49.6
N.A.
N.A.
P-Site Identity:
100
100
100
13.3
N.A.
73.3
80
N.A.
N.A.
86.6
N.A.
66.6
60
N.A.
0
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
86.6
93.3
N.A.
N.A.
86.6
N.A.
80
80
N.A.
6.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
20
10
0
0
20
0
0
0
0
0
0
0
10
10
% A
% Cys:
0
0
10
0
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
70
0
20
0
0
0
0
0
0
0
0
10
80
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
40
50
0
20
0
0
80
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
10
0
10
0
0
10
0
0
20
80
0
10
0
60
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
0
20
10
90
20
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
10
80
10
80
0
0
0
0
0
0
0
0
% R
% Ser:
0
40
0
20
10
40
10
90
10
80
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% T
% Val:
0
0
10
0
0
0
0
0
0
0
20
60
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _